Presented by Sally Hed Dahlquist, President
Originally aired November 10, 2020
What will you learn?
- How lysosome function is used as a reliable indicator of cell health and toxicity
- The activity of cathepsins inside lysosomes, in the cytosol, and in the extracellular matrix
- How cathepsins are tightly regulated to prevent uncontrolled proteolytic activity which can lead to diseases like cancer
- How lysosomes and cathepsins play a role in diseases such as Alzheimer’s, Parkinson’s, cancer, and malaria
- Impact of calcium to regulate pH in the lysosome
- Apoptosis, Autophagy, Mitosis, and Mitochondrial health
- Techniques to easily measure cathepsin activity and lysosome function in cultured cells, including neurons, with examples using microfluidic devices, and transgenic models using GFP
Who may this interest?
- Scientists interested in easy techniques to determine cell health by monitoring organelles
- Researchers discovering drugs to treat neurological disorders and cancer, etc.
- Diagnostics labs running toxicity studies
At ICT, we are on a mission to help cure disease and we do that by providing better assays to study lysosomal functionality, cell viability, and cathepsins. Watch this webinar to understand the role of lysosomes and cathepsins, and how they impact cell viability, apoptosis, autophagy, mitosis, and mitochondrial function.
We are excited to share some of the work that’s been done on lysosomes and cathepsins. ICT’s products have been used by researchers all over the world and there are a lot of interesting ways they have been used to look at lysosome functionality in cultured cells, neurons, and related cells. In this webinar, we’ll highlight these experiments and explore the techniques and models of disease they used to evaluate cell health and toxicity by studying organelles such as lysosomes and mitochondria. These assays help researchers understand the pathway of disease, monitor disease progression and determine efficacy of treatment, that will ultimately lead to better treatment, and that’s why we’re all here, to help cure disease and save lives.