Swine CXCL11 Recombinant Protein

$180.00

Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small, interferon-inducible cytokine belonging to the CXC chemokine family. Along with homologous ELR-negative CXC chemokines CXCL9 (MIG) and CXCL10 (IP-10), CXCL11 facilitates selective recruitment of mononuclear leukocytes, natural killer cells, and plasmacytoid dendritic cells to sites of inflammation. Swine CXCL11 Recombinant Protein is purified CXCL11 produced in yeast.

Catalog # Product Size Quantity Price
6362 5 µg $180.00
Catalog #: 6362 Category:

Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small cytokine belonging to the CXC chemokine family. It is also commonly called Interferon-inducible T-cell alpha chemoattractant (I-TAC). There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes.

CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC) are homologous, interferon-inducible members of the CXC chemokine family that lack the tripeptide structure/function motif Glu-Leu-Arg (ELR) important in neutrophil chemoattraction. As such, these interferon-inducible ELR-negative CXC chemokines signal through a common receptor, CXCR3, to facilitate selective recruitment of mononuclear leukocytes, natural killer cells, and plasmacytoid dendritic cells to sites of inflammation.

The Swine CXCL11/I-TAC protein can be used in cell culture, as a CXCL11/I-TAC ELISA Standard, and as a Western Blot Control.

• Protein Sequence: FPMFKAGRCL CIGPGVKAVK VADIEKVSII HPSNNCDKTE VIVTLKAHKG RRCLNPKSKQ ANVIMKKVER MNFLRYQNV (79)
• Alias: I-TAC
• Source: yeast
• Molecular Weight: 8.9 kDa
• Form: Lyophilized
• Contains: Recombinant proteins produced in yeast
• Storage: -20°C
• Shipping: Ships at ambient temperature, Ships overnight (domestic), International Priority Shipping

Han J, Gu MJ, Yoo I, Choi Y, Jang H, Kim M, Yun CH, Ka H. Analysis of cysteine-X-cysteine motif chemokine ligands 9, 10, and 11, their receptor CXCR3, and their possible role on the recruitment of immune cells at the maternal-conceptus interface in pigs. Biol Reprod. 2017 Jul 1;97(1):69-80. doi: 10.1093/biolre/iox074. Abstract

“The inserts were preincubated in RPMI 1640 containing 5% FBS for 1 h. Media were removed, and the inserts were then placed into wells containing 500 μl media containing different doses (0, 2, 5, 10, 30, or 90 ng/ml) of the recombinant porcine chemokines CXCL9 (rCXCL9), CXCL10 (rCXCL10), and CXCL11 (rCXCL11) (all from Immunochemistry Technologies, Bloomington, MN).”