IL-21 is a member of the type I cytokine family, which includes IL-2 and IL-15. IL-21 signals through the common gamma-chain and a unique IL-21 receptor. The IL-21 receptor is expressed in cells of lymphoid-lineage and regulates the proliferation and differentiation of T and B lymphocytes. Studies suggest that IL-21 is a key component of CD4 T cell help that is required for maintaining the CD8+ T cell responses and inducing B cell antibody response. IL-21 also promotes the development of Th17 and Tfh cells, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. It is also implicated in the development of autoimmune disease and has antitumor activity.
Canine IL-21 Recombinant Protein
The cytokine interleukin-21 (IL-21) regulates the proliferation and differentiation of T and B lymphocytes, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. Canine IL-21 Recombinant Protein is purified interleukin-21 produced in yeast.
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The Canine IL-21 protein can be used in cell culture, as an IL-21 ELISA Standard, and as a Western Blot Control.
• Protein Sequence: HKSSFQEQDL LLIRMRQLID IVDQLKNYVN DLDPESLPAP EDVKRHCERS AFSCFQKVQL KAANTGGNEQ IINVLTKQLK RKLPPTNAGR RQKHRPACPS CDSYEKAPPK EFLERLKSLI QKMIHQHLS (129)
• Alias: Interleukin-21
• Source: yeast
• Molecular Weight: 14.9 kDa
• Form: Lyophilized
• Contains: Recombinant proteins produced in yeast
• Storage: -20°C
• Shipping: Ships at ambient temperature, Ships overnight (domestic), International Priority Shipping