Bovine IL-6 Recombinant Protein

$180.00

Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Bovine IL-6 Recombinant Protein is purified interleukin-6 produced in yeast.

Catalog # Product Size Quantity Price
6371 5 µg $180.00
Catalog #: 6371 Category:

Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Its role as an anti-inflammatory cytokine is mediated through its inhibitory effects on TNF-alpha and IL-1, and activation of IL-1ra and IL-10.

IL-6 is secreted by T cells and macrophages to stimulate immune response to trauma, especially burns or other tissue damage leading to inflammation. IL-6 is also produced from muscle, and its levels are elevated in response to muscle contraction. Its levels are significantly elevated with exercise, and IL-6 precedes the appearance of other cytokines in the circulation. Osteoblasts secrete IL-6 to stimulate osteoclast formation. Smooth muscle cells in the tunica media of many blood vessels also produce IL-6 as a pro-inflammatory cytokine.

The biological activity of Bovine IL-6 has been confirmed by an independent laboratory. Bovine and Mouse Bone Marrow-Derived Macrophages (BMDM) responded to 10 ng/mL Bovine IL-6 by up-regulating the expected IL-6 responsive genes IL4R, SOCS3 (RT-PCR) and phospho-Stat3 (Western Blot).

The Bovine IL-6 protein can be used in cell culture, as an IL-6 ELISA Standard, and as a Western Blot Control.

• Protein Sequence: GPLGEDFKND TTPGRLLLTT PEKTEALIKR MVDKISAMRK EICEKNDECE SSKETLAENK LNLPKMEEKD GCFQSGFNQA ICLIRTTAGL LEYQIYLDYL QNEYEGNQEN VRDLRKNIRT LIQILKQKIA DLITTPATNT DLLEKMQSSN EWVKNAKIIL ILRNLENFLQ FSLRAIRMK (179)
• Alias: Interleukin-6
• Source: yeast
• Molecular Weight: 20.7 kDa
• Form: Lyophilized
• Contains: Recombinant proteins produced in yeast
• Storage: -20°C
• Shipping: Ships at ambient temperature, Ships overnight (domestic), International Priority Shipping