Interleukin-13 (IL-13) is secreted by many cell types, but especially T helper type 2 (Th2) cells. IL-13 is an important mediator of allergic inflammation and disease. In addition to effects on immune cells, IL-13 is implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. Thus, although IL-13 can induce immunoglobulin E (IgE) secretion from activated human B cells, deletion of IL-13 from mice does not markedly affect either Th2 cell development or antigen-specific IgE responses induced by potent allergens. In comparison, deletion of IL-4 abrogates these responses. Thus, rather than a lymphoid cytokine, IL-13 acts more prominently as a molecular bridge linking allergic inflammatory cells to the non-immune cells in contact with them, thereby altering physiological function. The biological activity of recombinant bovine IL-13 was measured in a cell proliferation assay using the human TF-1 cell line. The ED50 for this effect is typically 20 – 30 ng/mL.
Bovine IL-13 Recombinant Protein
IL-13 is an important mediator of allergic inflammation and disease. In addition to effects on immune cells, IL-13 is implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. Bovine IL-13 Recombinant Protein is purified interleukin-13 produced in yeast.
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The Bovine IL-13 protein can be used in cell culture, as an IL-13 ELISA Standard, and as a Western Blot Control.
• Protein Sequence: SPVPSATALK ELIEELVNIT QNQKVPLCNG SMVWSLNLTS SMYCAALDSL ISISNCSVIQ RTKKMLNALC PHKPSAKQVS SEYVRDTKIE VAQFLKDLLR HSRIVFRNER FN (112)
• Alias: Interleukin-13
• Source: yeast
• Molecular Weight: 12.6 kDa
• Form: Lyophilized
• Contains: Recombinant proteins produced in yeast
• Storage: -20°C
• Shipping: Ships at ambient temperature, Ships overnight (domestic), International Priority Shipping