Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small cytokine belonging to the CXC chemokine family. It is also commonly called Interferon-inducible T-cell alpha chemoattractant (I-TAC). There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative). ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC) are homologous, interferon-inducible members of the CXC chemokine family that lack the tripeptide structure/function motif Glu-Leu-Arg (ELR) important in neutrophil chemoattraction. As such, these interferon-inducible ELR-negative CXC chemokines signal through a common receptor, CXCR3, to facilitate selective recruitment of mononuclear leukocytes, natural killer cells, and plasmacytoid dendritic cells to sites of inflammation. Bovine CXCL11 can be used in cell culture, as an ELISA Standard, and as a Western Blot Control.
Bovine CXCL11 Recombinant Protein
Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small, interferon-inducible cytokine belonging to the CXC chemokine family. Along with homologous ELR-negative CXC chemokines CXCL9 (MIG) and CXCL10 (IP-10), CXCL11 facilitates selective recruitment of mononuclear leukocytes, natural killer cells, and plasmacytoid dendritic cells to sites of inflammation. Bovine CXCL11 Recombinant Protein is purified CXCL11 produced in yeast.
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The bovine CXCL11/I-TAC protein can be used in cell culture, as a CXCL11/I-TAC ELISA Standard, and as a Western Blot Control.
• Protein Sequence: FPMFKGGRCL CIGPGVKAVK VADIEKVSII YPTNNCDKTE VIITLKTHKG QRCLNPKAKQ AKAIIKKVQR KNSEKYKNI (79)
• Alias: I-TAC
• Source: yeast
• Molecular Weight: 8.8 kDa
• Form: Lyophilized
• Contains: Recombinant proteins produced in yeast
• Storage: -20°C
• Shipping: Ships at ambient temperature, Ships overnight (domestic), International Priority Shipping