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IN VIVO MONITORING OF APOPTOSIS DURING EXPERIMENTAL ANTI-CANCER TREATMENT using NIR FLIVO 747 Tracer Control Group and Experimental Group Mice

Apoptotic tissues in murine tumor models were imaged in vivo with NIR-FLIVO® 747 Tracer (*Dylight® 747-VAD-FMK, kit #9114) us¬ing the CRi Maestro™ imaging system. NIR-FLIVO 747 was used to non-invasively monitor the efficacy and time kinetics of an experimental anti-cancer treatment. After receiving a placebo or an experimental treatment, negative control mice (left image) and experimentally treated mice (right image) were injected intravenously with NIR-FLIVO 747 Tracer and imaged non-invasively at various time points with the CRi Maestro™ imaging system. Apoptotic tumor tissues fluoresce bright blue in the experimental group subjects, indicating that the experimental treatment had an apoptotic effect.