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DETECTION OF APOPTOSIS IN MURINE BRAIN ABSCESSES USING NIR-FLIVO 690 TRACER 690 Free Dye Control and NIR FLIVO 690 Tracer Data

Brain abscesses were induced in mice following the intracerebral inoculation of live Staphylococcus aureus. Animals received intravenous injections of NIR-FLIVO 690 Tracer (kit #9112) or NIR-FLIVO 690 Free Dye Control (kit #9113) at 17 hours post-infection, whereupon signals were acquired 1 hour later from brain tissues ex vivo using an IVIS® Spectrum™ (Caliper Life Sciences). Strong caspase activity was associated with brain abscesses following administration of the NIR-FLIVO 690 Tracer (right image), whereas minimal signal was detected in animals injected with the NIR-FLIVO 690 Free Dye Control (left image).