A new blog post from our sister company Antibodies Inc discusses the connection between Tyrosine Hydroxylase and Parkinson’s.
Industry-leading Antibodies to Power Your Parkinson’s Disease Research!
A feature common to all neurodegenerative parkinsonian disorders is loss of dopaminergic neurons of the substantia nigra. Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the biosynthesis of catecholamines, including the neurotransmitter dopamine, and is widely used as a marker of dopaminergic neurons.
Tyrosine Hydroxylase (TH):
TH is the rate-limiting enzyme in the synthesis of the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine and is responsible for converting L-tyrosine to L-dopa. Synthesis of catecholamines is regulated by the interaction of TH with its cofactor, tetrahydrobiopterin (BH4) and the substrates L-tyrosine and molecular oxygen. In humans, four TH mRNA splice variants (hTH1-hTH4) have been isolated, while subprimate species rely on a single form of TH. It is known that the hTH1-hTH4 variants are identical in their catalytic domain but differ in their N-terminal regulatory domains. Importantly, LNC1 reacts with the catalytic domain of TH and thus with all four isoforms of human TH. The role of TH in the synthesis of catecholamine neurotransmitters suggests a connection between the enzyme and a number of neuropathogenic diseases characterized by irregular catecholamine levels, such as Parkinson’s disease, schizophrenia, and dystonia, as well as a variety of cardiovascular diseases.
Antibodies Incorporated’s Mouse Monoclonal anti-Tyrosine Hydroxylase antibody LNC1 is the most widely-cited anti-TH antibody with over 2,500 citations to date. It is available in two sizes, 20 µl and 100 µl.
Double-labeled fluorescence immunohistochemistry of human midbrain dopamine neurons stained green with LNC1 and red with PitX.
For researchers needing to multiplex their anti-Tyrosine Hydroxylase staining with antibodies from alternative host species we also offer the following high quality anti-TH antibodies:
Please see our product page for more information.